GROUP LEADER
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Qualifications
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Selected achievements
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Dr Sovan Sarkar is a Birmingham Fellow (equivalent to Assistant Professor) at the University of Birmingham, and holds the distinction of Former Fellow for life at Hughes Hall, University of Cambridge. He studies the biological process of autophagy, which is an intracellular degradation pathway essential for cellular survival. Utilizing human embryonic stem cells (hESCs) and disease-specific human induced pluripotent stem cells (hiPSCs) to establish human cellular platforms, his lab works on the regulation and therapeutic application of autophagy in relation to human physiology and diseases. He aims to develop a pipeline originating from basic biology to drug discovery, and potentially translate the findings for biomedical applications. He has made several contributions in the field of autophagy including the identification of mTOR-independent signalling pathways and small molecules modulating autophagy. These findings not only provided mechanistic insights into the cell biology of this process, but also generated potential therapeutic candidates for diverse human diseases, including neurodegenerative diseases where upregulating autophagy acts as a protective pathway. His work also involves the fundamental regulation of autophagy in physiologically-relevant hESCs, and its deregulation in disease-relevant cell-types differentiated from hiPSC models. He has co-authored more than 50 scientific publications, which have collectively received over 15000 citations (Google Scholar), and have generated a number of patents and research features. He is also involved in scientific engagements with institutions in India as part of the University of Birmingham India Institute.
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Affiliations
Associations
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https://orcid.org/0000-0002-9456-4362PRESENT LAB MEMBERS
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Elena Seranova received her
MSc in Translational Neuroscience from University of Sheffield, UK. She is currently working on the therapeutic manipulation of autophagy using human pluripotent stem cell models, and is interested in drug discovery. |
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Malgorzata Zatyka received her PhD from the Institute of Biochemistry and Biophysics at Polish Academy of Sciences in Warsaw. She is currently a senior postdoctoral scientist, jointly with Prof. Timothy Barrett's lab, studying the mechanisms of defective autophagy underlying rare, childhood-onset neurodegenerative disorders using mammalian cell lines and human induced pluripotent stem cell-based neuronal models.
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Congxin Sun received her BSc in Pharmacology and MSc in Drug Design from University College London in UK. She is interested in the application of human pluripotent stem cell based platforms for drug discovery.
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Adina Maria Palhegyi received her BSc in Biomedical Science from University of Birmingham
in UK with a first class degree. She is studying the impact of autophagy and mitochondrial dysfunction on neuronal homeostasis using human embryonic stem cell and disease-specific human induced pluripotent stem cell-based platforms. |
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Tatiana Rosenstock is an Assistant Professor at Santa Casa Medical School in Sao Paulo, Brazil. She is a visiting faculty supported by the University of Birmingham Brazil Visiting Fellowship and Rutherford Fellowship. She is interested in studying the role of mitophagy and mitochondrial dysfunction in neurodegenerative diseases using cell models including human induced pluripotent stem cell-based disease platforms.
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Larissa Mendes Bomfim is a PhD student at Oswaldo Cruz Foundation (FIOCRUZ), Gonçalo Moniz Institute (IGM) in Salvador, Brazil. She is funded by the Print Capes-Fiocrus Fellowship from the Brazilian Federal Agency for Support of Graduate Education. She is interested to characterize novel compounds and signaling pathways regulating autophagy for biomedical applications.
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PAST LAB MEMBERS
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COLLABORATORS
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LAB GROUP PHOTOS
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