Sovan Sarkar Lab
Menu

PEOPLE

home
research
publications
patents
people
resources
news
contact

GROUP LEADER

Picture

Qualifications

  • BSc Physiology, Presidency College, University of Calcutta, India
  • MSc Biotechnology, Madurai Kamaraj University, India
  • PhD Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, UK
  • Postdoctoral Research Associate, Cambridge Institute for Medical Research, University of Cambridge, UK
  • Postdoctoral Associate, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, USA

Selected achievements

  • Rajiv Gandhi Science Talent Research Fellow (2000)
  • Gates Cambridge Scholarship (2002)
  • Junior Research Fellowship at Hughes Hall, University of Cambridge (2007-2010)
  • Former Fellow distinction at Hughes Hall, University of Cambridge (2010-Life)
  • Biochemical Society Early Career Research Award (2012)
  • Birmingham Fellowship (2014)
  • Identified mTOR-independent autophagy modulators and pathways for therapeutic intervention in human diseases
Dr Sovan Sarkar is a Birmingham Fellow (equivalent to Assistant Professor) at the University of Birmingham, and holds the distinction of Former Fellow for life at Hughes Hall, University of Cambridge. He studies the biological process of autophagy, which is an intracellular degradation pathway essential for cellular survival. Utilizing human embryonic stem cells (hESCs) and disease-specific human induced pluripotent stem cells (hiPSCs) to establish human cellular platforms, his lab works on the regulation and therapeutic application of autophagy in relation to human physiology and diseases. He aims to develop a pipeline originating from basic biology to drug discovery, and potentially translate the findings for biomedical applications. He has made several contributions in the field of autophagy including the identification of mTOR-independent signalling pathways and small molecules modulating autophagy. These findings not only provided mechanistic insights into the cell biology of this process, but also generated potential therapeutic candidates for diverse human diseases, including neurodegenerative diseases where upregulating autophagy acts as a protective pathway. His work also involves the fundamental regulation of autophagy in physiologically-relevant hESCs, and its deregulation in disease-relevant cell-types differentiated from hiPSC models. He has co-authored more than 50 scientific publications, which have collectively received over 15000 citations (Google Scholar), and have generated a number of patents and research features. He is also involved in scientific engagements with institutions in India as part of the University of Birmingham India Institute.
Follow @SarkarSovan
ORCID iD iconhttps://orcid.org/0000-0002-9456-4362

Affiliations

Picture
Picture
Picture

Associations

Picture
Picture

PRESENT LAB MEMBERS

Picture
Malgorzata Zatyka received her PhD from the Institute of Biochemistry and Biophysics at Polish Academy of Sciences in Warsaw, previously worked at the University of Birmingham. She is currently a senior postdoctoral scientist studying the mechanisms of defective autophagy underlying rare, childhood-onset neurodegenerative disorders using mammalian cell lines and human induced pluripotent stem cell-based neuronal models.
Picture
Dewi Astuti received her PhD from the University of Wales (Swansea). She previously worked at the University of Indonesia (Jakarta) and University of Birmingham, and is currently a postdoctoral scientist. Her work involves establishing chemical screening platforms using human pluripotent stem cell-based platforms.
Picture
Congxin Sun received her BSc in Pharmacology and MSc in Drug Design from University College London in UK. She is interested in the application of human pluripotent stem cell based platforms for understanding disease mechanisms and drug discovery. Her PhD work involves establishing chemical screening platforms and studying the homeostatic role of autophagy in human neurons.
Picture
Miriam Korsgen received her BSc in Biochemistry and Molecular Medicine from the University of Notthingham in UK, where she received the best student award in her graduating class. She is currently a PhD student, having received the BBSRC and University of Birmingham funded MIBTP PhD studentship. She is working on the regulation and metabolic functions of autophagy using human embryonic stem cell-based platforms.
Picture
Gamze Kocak is a PhD student at Dokuz Eylul University in Izmir, Turkey. She is currently a visiting PhD student funded by TUBITAK Fellowship from the Scientific and Technological Research Council of Turkey. Using human pluripotent stem cell models, she is studying the role of autophagy in the generation of organoids, and the mechanisms and consequences of defective autophagy in neurodegenerative diseases.
Picture
Leticia Fernandez Amores received her BSc in Biochemistry from Liverpool John Moores University in UK. She is currently a MSc by Research student at the University of Birmingham. She is investigating the mechanisms and consequences of autophagy dysfunction, and therapeutic benefits with autophagy inducers, in a rare childhood-onset neurodegenerative disorder using human neuronal and induced pluripotent stem cell models.
Picture
Asmaa Ghazwani received her PhD in Medicine from Cardiff University in UK. She is currently a postdoctoral researcher studying defective autophagy in two rare autosomal recessive childhood-onset neurodegenerative diseases. Her work involves evaluating the therapeutic benefits of FDA-approved autophagy-inducing compounds in neuronal cell models of rare diseases.
Picture
Ebony Hill received her BSc in Biological Sciences from University of Hull in UK. She is currently studying MSc in Genomic Medicine at the University of Birmingham. She is interested in rare diseases. She is studying the role of NAD and the biomedical implications of NAD boosting compounds in neuronal cell models of rare neurodegenerative diseases.
Picture
Yi (Doris) Yau received BSc in Biomedical Science from the University of Birmingham in UK. She is a visiting research internship student, currently studying Medicine at the University of Birmingham. She continues her work from the undergraduate project involving the mechsnisms and characterization of autophagy defect in a rare early-onset neurodegenerative disorder using cellular and in vivo models.

PAST LAB MEMBERS

Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture

LAB MEMBER COUNTRIES

Over the years, we have wide cultural representation in the lab with the lab members coming from various countries around the world.
Picture

COLLABORATORS

Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture

LAB GROUP PHOTOS

Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture
Picture

Powered by Create your own unique website with customizable templates.
  • Home
  • Research
  • Publications
  • Patents
  • People
  • Resources
  • News
  • Contact
  • Home
  • Research
  • Publications
  • Patents
  • People
  • Resources
  • News
  • Contact